### Mplus Data Analysis Examples Latent Class Analysis

#### Examples of Latent Class Analysis

Example 1. You are interested in studying drinking behavior among adults. Rather than conceptualizing drinking behavior as a continuous variable, you conceptualize it as forming distinct categories or typologies. For example, you think that people fall into one of three different types: abstainers, social drinkers and alcoholics. Since you cannot directly measure what category someone falls into, this is a latent variable (a variable that cannot be directly measured). However, you do have a number of indicators that you believe are useful for categorizing people into these different categories. Using these indicators, you would like to:

1. Create a model that permits you to categorize these people into three different types of drinkers, hopefully fitting your conceptualization that there are abstainers, social drinkers and alcoholics.
2. Be able to categorize people as to what kind of drinker they are.
3. Count how many people would be considered abstainers, social drinkers and alcoholics.
4. Determine whether three latent classes is the right number of classes (i.e., are there only two types of drinkers or perhaps are there as many as four types of drinkers).

Example 2. High school students vary in their success in school. This might be indicated by the grades one gets, the number of absences one has, the number of truancies one has, and so forth. A traditional way to conceptualize this might be to view "degree of success in high school" as a latent variable (one that you cannot directly measure) that is normally distributed. However, you might conceptualize some students who are struggling and having trouble as forming a different category, perhaps a group you would call "at risk" (or in older days they would be called "juvenile delinquents"). Using indicators like grades, absences, truancies, tardies, suspensions, etc., you might try to identify latent class memberships based on high school success.

#### Description of the Data

Let's pursue Example 1 from above. We have a hypothetical data file that we created that contains 9 fictional measures of drinking behavior. For each measure, the person would be asked whether the description applies to him/herself (yes or no). The 9 measures are
1. I like to drink
2. I drink hard liquor
3. I have drank in the morning
4. I have drank at work
5. I drink to get drunk
6. I like the taste of alcohol
7. I drink help me sleep
8. Drinking interferes with my relationships
9. I frequently visit bars

We have made up data for 1000 respondents and stored the data in a file called lca1.dat, which is a comma-separated file with the subject id followed by the responses to the 9 questions, coded 1 for yes and 0 for no. Using Stata, here is what the first 10 cases look like

list id item1-item9 in 1/10

+----------------------------------------------------------------------------+
| id   item1   item2   item3   item4   item5   item6   item7   item8   item9 |
|----------------------------------------------------------------------------|
1. |  1       1       0       0       0       0       0       0       0       0 |
2. |  2       1       1       0       1       1       1       1       0       0 |
3. |  3       1       0       0       0       0       0       0       0       0 |
4. |  4       1       0       0       0       0       1       1       0       0 |
5. |  5       1       0       0       0       1       0       0       0       1 |
|----------------------------------------------------------------------------|
6. |  6       0       1       0       0       0       1       0       0       0 |
7. |  7       1       1       0       0       0       0       0       0       1 |
8. |  8       1       0       1       0       0       0       0       0       0 |
9. |  9       1       0       0       0       0       0       0       1       0 |
10. | 10       0       0       0       0       0       1       0       0       0 |
+----------------------------------------------------------------------------+

#### Some Strategies You Might Try

Before we show how you can analyze this with Latent Class Analysis, let's consider some other methods that you might use:
• Cluster Analysis - You could use cluster analysis for data like these. However, cluster analysis is not based on a statistical model. It can tell you how the cases are clustered into groups, but it does not provide information such as the probability that a given person is an alcoholic or abstainer. Also, cluster analysis would not provide information such as: given that someone said "yes" to drinking at work, what is the probability that they are an alcoholic.
• Factor Analysis - Because the term "latent variable" is used, you might be tempted to use factor analysis since that is a technique used with latent variables. However, factor analysis is used for continuous and usually normally distributed latent variables, where this latent variable, e.g., alcoholism, is categorical.

#### Mplus Results Using Latent Class Analysis

Note that I am showing you results before showing you the program. I will show you the program later.

Conditional Probabilities

First, the probability of answering "yes" to each question is shown for each type of drinker (latent class). For example, consider the question "I have drank at work". The probability of answering "yes" to this might be 70% for the first class, 10% for the second class, and 9% for the third class. This would be consistent with the first class being alcoholics. Looking at the pattern of responses for all classes gives you an overall picture of the meaning of the three classes that are identified and helps us create descriptive labels for the classes. We are hoping to find three classes that correspond to abstainers, social drinkers, and alcoholics. Abstainers would have a pattern that they generally avoid drinking, social drinkers would show a pattern of drinking but generally in moderation and seldom in self-destructive ways, while alcoholics would show a pattern of drinking frequently and in very self-destructive ways.

The Mplus output shows a section labeled

RESULTS IN PROBABILITY SCALE

which contains the conditional probabilities as describe above, but it is hard to read. I have reformatted that output to make it easier to read, shown below. Each row represents a different item, and the three columns of numbers are the probabilities of answering "yes" to the item given that you belonged to that class. So, if you belong to Class 1, you have a 90.8% probability of saying "yes, I like to drink". By contrast, if you belong to Class 2, you have a 31.2% chance of saying "yes, I like to drink".

         Class 1  Class 2  Class 3    Item Label
ITEM1    0.908    0.312    0.923     I like to drink
ITEM2    0.337    0.164    0.546     I drink hard liquor
ITEM3    0.067    0.036    0.426     I have drank in the morning
ITEM4    0.065    0.056    0.418     I have drank at work
ITEM5    0.219    0.044    0.765     I drink to get drunk
ITEM6    0.320    0.183    0.471     I like the taste of alcohol
ITEM7    0.113    0.098    0.512     I drink help me sleep
ITEM8    0.140    0.110    0.619     Drinking interferes with my relationships
ITEM9    0.325    0.188    0.349     I frequently visit bars                  

Looking at item1, those in Class 1 and Class 3 really like to drink (with 90.8% and 92.3% saying yes) while those in Class 2 are not so fond of drinking (they have only a 31.2% probability of saying they like to drink).  Jumping to item5, 76.5% of those in Class 3 say they drink to get drunk, while 21.9% of those in Class 1 agreed to that, and only 4.4% of those in Class 2 say that.

I am starting to believe that Class 3 may be labeled as "alcoholics". Focusing just on Class 3 (looking at that column), they really like to drink (92%), drink hard liquor (54.6%), a pretty large number say they have drank in the morning and at work (42.6% and 41.8%), and well over half say drinking interferes with their relationships (61.9%).

It seems that those in Class 2 are the "abstainers" we were hoping to find. Not many of them like to drink (31.2%), few like the taste of alcohol (18.3%), few frequently visit bars (18.8%), and for the rest of the questions they rarely answered "yes".

This leaves Class 1; might they fit the idea of the "social drinker"? They like to drink (90.8%), but they don't drink hard liquor as often as Class 3 (33.7% versus 54.6%). They rarely drink in the morning or at work (6.7% and 6.5%) and rarely say that drinking interferes with their relationships (14%). They say they frequently visit bars similar to Class 3 (32.5% versus 34.9%), but that might make sense. Both the social drinkers and alcoholics are similar in how much they like to drink and how frequently they go to bars, but differ in key ways such as drinking at work, drinking in the morning, and the impact of drinking on their relationships.

While we should study these conditional probabilities some more, I think we can start to assign labels to these classes. As I hypothesized, the classes seem to make sense to be labeled "social drinkers" (which is Class 1), "abstainers" (which is Class 2), and "alcoholics" (which is Class 3).

We can also take the results from the above table and express it as a graph. The X axis represents the item number and the Y axis represents the probability of answering "yes" to the given item, given that you belong to a particular drinking class. The three drinking classes are represented as the three different lines.

Class Membership

For each person, Mplus will estimate what class the person belongs to (i.e., what type of drinker the person is). For a given person, Mplus estimates the probability that the person belongs to the first, second, or third class. For example, for subject 1 these probabilities might be 15% that the person belongs to the first class, 80% probability of belonging to the second class, and 5% of belonging to the third class. For such a person I would say that I think the person belongs to the second class since that class was the most likely. Mplus will also categorize people into a single class using the same kind of rule.

Mplus creates an output file which contains the original data used in the analysis (i.e., item1 to item9) followed by the probability that Mplus estimates that the observation belongs to Class 1, Class2, and Class 3. Next, the class with the highest probability (the modal class) is shown. I have taken a snippet of the output and labeled it to make it easier to read.

Items 1 - 9
----------------- P(c1) P(c2) P(c3) Class
1 0 0 0 0 0 0 0 0 0.645 0.354 0.001 1
1 1 0 1 1 1 1 0 0 0.098 0.001 0.901 3
1 0 0 0 0 0 0 0 0 0.645 0.354 0.001 1
1 0 0 0 0 1 1 0 0 0.797 0.177 0.026 1
1 0 0 0 1 0 0 0 1 0.934 0.041 0.025 1
0 1 0 0 0 1 0 0 0 0.312 0.686 0.002 2
1 1 0 0 0 0 0 0 1 0.903 0.092 0.005 1
1 0 1 0 0 0 0 0 0 0.766 0.218 0.017 1
1 0 0 0 0 0 0 1 0 0.696 0.290 0.014 1
0 0 0 0 0 1 0 0 0 0.149 0.850 0.000 2         

For the first observation, the pattern of responses to the items suggests that the person has a 64.5% chance of being in Class 1 (which we called social drinkers), a 35.4% chance of being in Class 2 (abstainer), and a 0.1% chance of being in Class 3 (alcoholic). Note that these sum to 100% (since a person has to be in one of these classes). For this person, Class 1 is the most likely class, and Mplus indicates that in the last column. It is interesting to note that for this person, the pattern of results made it almost certain that s/he was not alcoholic, but it was less clear whether s/he was a social drinker or an abstainer (perhaps because the person said "yes" to item 1 (I like to drink). Note how the third row of data has the same pattern of responses for the items and has the same predicted class probabilities. Consider row 2 of the data. This person has a 90.1% chance of being an alcoholic, a 9.8% chance of being a social drinker, and a 0.1% chance of being an abstainer. One important point to note here is that for some subjects, the class membership is pretty well determined (like subject 2), while it is a bit more ambiguous (like subjects 1 and 3) where there is no single class that they certainly belong to.

Size of Classes

Once we have come up with a descriptive label for each of the classes, we can look at the number of people who are categorized into each of the classes. I predict that about 20% of people are abstainers, 70% are social drinkers, and about 10% are alcoholics. I can compare my predictions to the results that Mplus produces.

How many alcoholics are there? How many abstainers are there? How many social drinkers are there? One simple way we could determine this is by taking the information from the Class Membership above and doing a simple tabulation on the last column. In fact, the Mplus output provides this to you like this.

CLASSIFICATION OF INDIVIDUALS BASED ON THEIR MOST LIKELY LATENT CLASS MEMBERSHIP

Class Counts and Proportions

Latent
Classes
1              646          0.64600
2              288          0.28800
3               66          0.06600

Out of the 1,000 subjects we had, 646 (64.6%) are categorized as Class 1 (which we label as social drinkers), 66 (6.6%) are categorized as Class 3 (alcoholics), and 288 (28.8%) are categorized as Class 2 (abstainers). This is consistent with my hunches that most people are social drinkers, a very small portion are alcoholics, and a moderate portion are abstainers.

There is a second way we could compute the size of the classes. Consider subject 1 from the above output on class membership. Rather than considering this person as entirely belonging to class 1, we could allocate membership to the classes in proportion to the probability of being in each class. So, subject 1 has fractional memberships in each class, 0.645 to Class 1, 0.001 to Class 3, and 0.354 to Class 2. Mplus also computes the class sizes in this manner, as shown below.

FINAL CLASS COUNTS AND PROPORTIONS FOR THE LATENT CLASS PATTERNS
BASED ON ESTIMATED POSTERIOR PROBABILITIES

Latent
Classes
1        557.56836          0.55757
2        363.13989          0.36314
3         79.29175          0.07929

These two methods yield largely similar results, but this second method suggests that there are somewhat more abstainers (36.3%) compared to the previous method (28.8%) and slightly fewer social drinkers (55.7% compared to 64.6%), but these differences are not very troublesome to me.

#### Number of Classes

So far we have been assuming that we have chosen the right number of latent classes. Perhaps, however, there are only two types of drinkers, or perhaps there are four or more types of drinkers. So far we have liked the three class model, both based on our theoretical expectations and based on how interpretable our results have been. We can further assess whether we have chosen the right number of classes using the Vuong-Lo-Mendell-Rubin test (requested using TECH11, see Mplus program below) and the bootstrapped parametric likelihood ratio test (requested using TECH 14, see Mplus program below). This test compares the model with K classes (in our case 3) to a model with (K-1) classes (in our case, K - 1 = 2 classes). The results are shown below.

TECHNICAL 11 OUTPUT

VUONG-LO-MENDELL-RUBIN LIKELIHOOD RATIO TEST FOR 2 (H0) VERSUS 3 CLASSES
H0 Loglikelihood Value                        -4251.208
2 Times the Loglikelihood Difference             39.025
Difference in the Number of Parameters               10
Mean                                             20.255
Standard Deviation                               22.224
P-Value                                          0.1457

Value                                            38.468
P-Value                                          0.1500

TECHNICAL 14 OUTPUT

BOOTSTRAPPED PARAMETRIC LIKELIHOOD RATIO TEST FOR 2 (H0) VERSUS 3 CLASSES
H0 Loglikelihood Value                        -4251.208
2 Times the Loglikelihood Difference             39.025
Difference in the Number of Parameters               10
Approximate P-Value                              0.0000

The Vuong-Lo-Mendell-Rubin test has a p-value of .1457 and the Lo-Mendell-Rubin adjusted LRT test has a p-value of .1500. Those tests suggest that two classes are sufficient and that three classes are not really needed. However, the bootstrapped parametric likelihood ratio test has a p value of 0.0000, so this test suggests that three classes are indeed better than two classes. Because we have seen unpublished results that suggest that the bootstrap method may be more reliable, and the three class model fits our theoretical expectations, we will go with the three class model.

#### The Mplus Program

Here is the whole Mplus program

Title:
Fictitous Latent Class Analysis.
Data:
File is lca1.dat ;
Variable:
names        = id item1 item2 item3 item4 item5 item6 item7 item8 item9;
usevariables = item1 item2 item3 item4 item5 item6 item7 item8 item9;
categorical  = item1 item2 item3 item4 item5 item6 item7 item8 item9;
classes = c(3);
Analysis:
Type=mixture;
Plot:
type is plot3;
series is item1 (1) item2 (2) item3 (3) item4 (4) item5 (5)
item6 (6) item7 (7) item8 (8) item9 (9);
Savedata:
file is lca1_save.txt ;
save is cprob;
format is free;
output:
tech11 tech14;

Let's look at the pieces of this program.

Title:
Fictitous Latent Class Analysis.
Data:
File is lca1.dat ;
Variable:
names        = id item1 item2 item3 item4 item5 item6 item7 item8 item9;
usevariables = item1 item2 item3 item4 item5 item6 item7 item8 item9;
categorical  = item1 item2 item3 item4 item5 item6 item7 item8 item9;
classes = c(3);
• The Title command gives a title to the program.
• The Data command tells Mplus about the data file, in particular that the data are stored in the file lca1.dat.
• The Variable command tells Mplus more about the variables in the data file. The names statement lists the names of the variables (in the order they appear in the data file). The usevariables statement indicates which variables we will use for this analysis. The categorical statement indicates that the specified variables are categorical variables. The classes statement indicates that there is one categorical latent variable (which we will call c), and it has 3 levels.

Here is more of the program.

Analysis:
Type=mixture;
Plot:
type is plot3;
series is item1 (1) item2 (2) item3 (3) item4 (4) item5 (5)
item6 (6) item7 (7) item8 (8) item9 (9);
• The Analysis command is used to specify that the type of analysis is a mixture model, which is how you request a latent class analysis.
• The Plot command is used to make the plot we created above. The type was plot3, and the series statement is used to associate the items with the X axis, with item1 labeled as 1, item2 labeled as 2 ... and item9 labeled as 9 on the X axis.

And here is the rest of the program.

Savedata:
file is lca1_save.txt ;
save is cprob;
format is free;
output:
tech11 tech14;
• The savedata command is used to save the original data file along with additional statistics in it. The data file will be named lca1_save.txt and the save statement indicates we want to save the class probabilities, i.e., for each case the probability that case belongs to class 1, class 2 and class 3. This also saves the modal class membership. The format of the file is free, space separated.
• The output command is used to request additional output. In this case, the tech11 option requests the Vuong-Lo-Mendell-Rubin test for assessing the number of classes and the tech14 option requests the bootstrapped parametric likelihood ratio test.

#### The Mplus Output

The output from Mplus can be a bit tricky to read, and there is quite a bit that can be disregarded. Feel free to come visit us in walk in consulting and we can walk through the output with you, relating it to the summarized version of the output described above.

#### All of the Files

Here are links to the program, data, output and saved data files.

#### Cautions, Flies in the Ointment

We have focused on a very simple example here just to get you started. Here are some problems to watch out for.
1. Have you specified the right number of latent classes? Perhaps you have specified too many classes (i.e., people largely fall into 2 classes) or you may have specified too few classes (i.e., people really fall into 4 or more classes).
2. Are some of your measures/indicators lousy? All of our measures were really useful in distinguishing what type of drinker the person was. However, say we had a measure that was "Do you like broccoli?". This would be a poor indicator, and each type of drinker would probably answer in a similar way, so this question would be a good candidate to discard.
3. Having developed this model to identify the different types of drinkers, we might be interested in trying to predict why someone is an alcoholic, or why someone is an abstainer. For example, we might be interested in whether parental drinking predicts being an alcoholic. Such analyses are possible, but not discussed here. (references forthcoming)

Forthcoming.